W | 2021-08-16 | 19:00 | Derby County U23 |  | 0-2 |  | Brighton & Hove Albion U23 | D1 | | | | |
W | 2021-08-20 | 19:00 | Brighton & Hove Albion U23 | | 4-2 |  | West Ham U23 | D2 | | | | |
D | 2021-08-29 | 13:00 | Liverpool U23 |  | 1-1 | | Brighton & Hove Albion U23 | D3 | | | | |
W | 2021-09-10 | 19:00 | Brighton & Hove Albion U23 | | 4-1 |  | Blackburn Rovers U23 | D4 | | | | |
L | 2021-09-17 | 12:00 | Manchester United U23 |  | 2-1 | | Brighton & Hove Albion U23 | D5 | | | | |
W | 2021-09-24 | 19:00 | Brighton & Hove Albion U23 | | 2-1 |  | Leicester City U23 | D6 | | | | |
L | 2021-10-01 | 19:00 | Arsenal U23 |  | 3-0 | | Brighton & Hove Albion U23 | D7 | | | | |
W | 2021-10-16 | 17:00 | Brighton & Hove Albion U23 | | 2-1 |  | Crystal Palace U23 | D8 | | | | |
D | 2021-10-22 | 19:00 | Leeds United U23 |  | 1-1 | | Brighton & Hove Albion U23 | D9 | | | | |
D | 2021-10-29 | 19:30 | Brighton & Hove Albion U23 | | 1-1 |  | Manchester City U23 | D10 | | | | |
D | 2021-11-05 | 19:00 | Brighton & Hove Albion U23 | | 1-1 |  | Tottenham U23 | D11 | | | | |
L | 2021-11-22 | 19:00 | Everton U23 |  | 2-1 | | Brighton & Hove Albion U23 | D12 | | | | |
D | 2021-11-26 | 19:00 | Chelsea U23 |  | 1-1 | | Brighton & Hove Albion U23 | D13 | | | | |
W | 2021-12-03 | 13:00 | Brighton & Hove Albion U23 | | 3-0 | | Liverpool U23 | D14 | | | | |
L | 2021-12-17 | 19:00 | Manchester City U23 | | 3-1 | | Brighton & Hove Albion U23 | D15 | | | | |
D | 2022-01-07 | 19:00 | Brighton & Hove Albion U23 | | 1-1 | | Arsenal U23 | D16 | | | | |
L | 2022-01-17 | 19:00 | Leicester City U23 | | 2-1 | | Brighton & Hove Albion U23 | D17 | | | | |
L | 2022-01-21 | 14:00 | Brighton & Hove Albion U23 | | 1-2 | | Manchester United U23 | D18 | | | | |
L | 2022-02-04 | 19:00 | Blackburn Rovers U23 | | 6-0 | | Brighton & Hove Albion U23 | D19 | | | | |
L | 2022-02-28 | 13:00 | Crystal Palace U23 | | 2-0 | | Brighton & Hove Albion U23 | D21 | | | | |
W | 2022-03-11 | 19:00 | Brighton & Hove Albion U23 | | 4-2 | | Everton U23 | D22 | | | | |
L | 2022-03-18 | 19:00 | West Ham U23 | | 3-2 | | Brighton & Hove Albion U23 | D23 | | | | |
W | 2022-04-04 | 19:00 | Brighton & Hove Albion U23 | | 5-1 | | Derby County U23 | D24 | | | | |
W | 2022-04-15 | 14:00 | Brighton & Hove Albion U23 | | 1-0 | | Leeds United U23 | D20 | | | | |
L | 2022-04-25 | 19:00 | Brighton & Hove Albion U23 | | 1-2 | | Chelsea U23 | D25 | | | | |
D | 2022-05-02 | 13:00 | Tottenham U23 | | 0-0 | | Brighton & Hove Albion U23 | D26 | | | | |
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