25/04 - 20:00
| 2021/11/29 | Tampa Bay Rowdies |  | 1-3 |  | Orange County SC |
| G | GS | GC | Pts | |||
|---|---|---|---|---|---|---|
| 1 | | Tampa Bay Rowdies | 32 | 55 | 23 | 71 |
| 2 |  | Charlotte Independence | 32 | 57 | 36 | 59 |
| 3 |  | Pittsburgh Riverhounds | 32 | 52 | 34 | 58 |
| 4 |  | Miami FC | 32 | 55 | 40 | 54 |
| 5 |  | Hartford Athletic | 32 | 50 | 50 | 41 |
| 6 |  | Charleston Battery | 32 | 49 | 60 | 37 |
| 7 |  | NY Red Bulls Reserve Squad | 32 | 42 | 67 | 28 |
| 8 |  | Loudoun United | 32 | 31 | 78 | 15 |
| G | GS | GC | Pts | |||
|---|---|---|---|---|---|---|
| 1 |  | Louisville City | 32 | 61 | 37 | 61 |
| 2 |  | Birmingham Legion | 32 | 51 | 31 | 60 |
| 3 |  | Memphis 901 | 32 | 47 | 42 | 50 |
| 4 |  | FC Tulsa | 32 | 49 | 48 | 47 |
| 5 |  | Oklahoma City Energy | 32 | 30 | 38 | 37 |
| 6 |  | Indy Eleven | 32 | 32 | 47 | 35 |
| 7 |  | Atlanta United Reserve Squad | 32 | 47 | 56 | 34 |
| 8 |  | Sporting KC Reserve Squad | 32 | 33 | 64 | 20 |
| G | GS | GC | Pts | |||
|---|---|---|---|---|---|---|
| 1 |  | El Paso Locomotive | 32 | 56 | 34 | 64 |
| 2 |  | San Antonio FC | 32 | 50 | 38 | 52 |
| 3 |  | Colorado Springs Switchbacks | 32 | 60 | 50 | 49 |
| 4 |  | Rio Grande Valley | 32 | 49 | 42 | 47 |
| 5 |  | New Mexico United | 32 | 44 | 40 | 46 |
| 6 |  | Austin Bold | 32 | 32 | 42 | 42 |
| 7 |  | Real Monarchs | 32 | 28 | 56 | 22 |
| G | GS | GC | Pts | |||
|---|---|---|---|---|---|---|
| 1 |  | Phoenix Rising | 32 | 68 | 35 | 67 |
| 2 | | Orange County SC | 32 | 44 | 37 | 52 |
| 3 |  | San Diego Loyal | 32 | 51 | 43 | 48 |
| 4 |  | Oakland Roots SC | 32 | 36 | 43 | 41 |
| 5 |  | LA Galaxy Reserve Squad | 32 | 55 | 57 | 39 |
| 6 |  | Tacoma Defiance | 32 | 37 | 41 | 39 |
| 7 |  | Sacramento Republic | 32 | 36 | 42 | 36 |
| 8 |  | Las Vegas Lights | 32 | 41 | 77 | 21 |
| Matchday | Date | Time | |||||
|---|---|---|---|---|---|---|---|
| 0 | L16 | Birmingham Legion | CANC | Pittsburgh Riverhounds | 2021-11-07 | 22:00 |
| 2 |
|
Sebastián Guenzatti Tampa Bay Rowdies | 22 G |
| 3 |
|
Kyle Murphy Memphis 901 | 21 G |
| 3 |
|
Cameron Lancaster Louisville City | 21 G |
| 5 |
|
Neco Brett Birmingham Legion | 18 G |
