25/04 - 20:00
| 2021/02/12 | Independiente Medellín |  | 1-1 (5-4 pens) |  | Tolima |
| 2021/01/13 | Quindío |  | 2-0 |  | Alianza Petrolera | ||||
| 2021/01/14 | Independiente Medellín | | 2-1 |  | Junior Barranquilla | ||||
| 2021/01/15 | Deportivo Pasto |  | 1-1 (3-1 pens) |  | América de Cali | ||||
| 2021/01/21 | Tolima | | 2-0 |  | Atlético Nacional |
| 1st Leg | 2nd Leg | |||||||
|---|---|---|---|---|---|---|---|---|
 | (1-1) | | 0-1 | 1-0 (3 pens-4) | ||||
 | (2-1) |  | 1-0 | 1-1 | ||||
 | (3-5) |  | 1-2 | 2-3 | ||||
 | (3-2) |  | 3-0 | 0-2 | ||||
 | (0-0) |  | 1-1 | 0-2 | ||||
 | (4-1) |  | 2-0 | 2-1 | ||||
 | (2-4) | | 2-0 | 0-4 | ||||
 | (3-4) |  | 1-3 | 2-1 | ||||
| (0-0) | | 2-1 | 2-1 |
| 1st Leg | 2nd Leg | |||||||
|---|---|---|---|---|---|---|---|---|
| (2-2) |  | 1-1 | 1-1 (4 pens-1) | ||||
 | (0-4) | | 0-2 | 0-2 | ||||
 | (1-1) | | 0-0 | 1-1 (1 pens-3) | ||||
 | (4-3) |  | 3-0 | 1-3 | ||||
 | (2-2) |  | 1-2 | 1-0 (3 pens-4) | ||||
 | (1-3) | | 0-1 | 1-2 | ||||
 | (4-2) |  | 0-2 | 4-0 | ||||
 | (2-3) |  | 1-2 | 1-1 |
| 2 |
|
Wilson España Quindío | 3 G |
| 2 |
|
Brayan Gil Alianza Petrolera | 3 G |
| 2 |
|
Matías Mier Independiente Medellín | 3 G |
| 5 |
|
Fredy Espinal Real San Andrés | 2 G |
