25/04 - 20:00
| Date | Time | Home | Away | Matchday | TV | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
D | 2022-01-13 | 02:06 | Santos Laguna |  | 1-1 |  | Tigres | D1 | ||||
L | 2022-01-16 | 18:00 | Toluca |  | 3-1 | | Santos Laguna | D2 | ||||
L | 2022-01-24 | 01:00 | Santos Laguna | | 1-4 |  | Necaxa | D3 | ||||
L | 2022-02-07 | 00:00 | Atlas |  | 2-1 | | Santos Laguna | D4 | ||||
L | 2022-02-13 | 03:00 | Santos Laguna | | 2-3 |  | América | D5 | ||||
D | 2022-02-19 | 03:00 | Juárez |  | 0-0 | | Santos Laguna | D6 | ||||
W | 2022-02-28 | 01:00 | Cruz Azul |  | 1-2 | | Santos Laguna | D7 | ||||
W | 2022-03-03 | 03:00 | Santos Laguna | | 3-2 |  | Pumas | D8 | ||||
L | 2022-03-06 | 03:00 | Chivas |  | 1-0 | | Santos Laguna | D9 | ||||
W | 2022-03-14 | 01:00 | Santos Laguna | | 4-0 |  | Club Tijuana | D10 | ||||
D | 2022-03-19 | 03:00 | Puebla |  | 2-2 | | Santos Laguna | D11 | ||||
W | 2022-04-04 | 01:00 | Santos Laguna | | 3-1 |  | Pachuca | D12 | ||||
L | 2022-04-10 | 01:06 | Monterrey |  | 1-0 | | Santos Laguna | D13 | ||||
D | 2022-04-17 | 01:00 | Santos Laguna | | 1-1 |  | Querétaro | D14 | ||||
L | 2022-04-20 | 03:00 | Mazatlán |  | 1-0 | | Santos Laguna | D15 | ||||
D | 2022-04-25 | 01:00 | Santos Laguna | | 1-1 |  | Club León | D16 | ||||
W | 2022-05-01 | 22:00 | Atlético San Luis |  | 1-3 | | Santos Laguna | D17 | ||||
