25/04 - 20:00
| 2021/12/05 | Philadelphia Union |  | 1-2 |  | New York City FC |
| 2 |
|
Hany Mukhtar Nashville SC | 19 G |
| 2 |
|
Ola Kamara DC United | 19 G |
| 4 |
|
Adam Buksa NE Revolution | 17 G |
| 4 |
|
Raúl Ruidíaz Seattle Sounders | 17 G |
| 1 |
|
Djordje Mihailovic CF Montréal | 14 AST |
| 3 |
|
Maxi Morález New York City FC | 13 AST |
| 4 |
|
Jack Price Colorado Rapids | 12 AST |
| 5 |
|
Hany Mukhtar Nashville SC | 10 AST |
