29/05 - 20:00
| h2h | 2021-11-21 | CF Montréal |  | 1-0 |  | Toronto FC | F | ||
| h2h | 2021-08-01 | FC Edmonton |  | 3-1 |  | Valour FC | L | ||
| h2h | 2021-06-24 | Sporting KC |  | 3-1 |  | Colorado Rapids | Grp.West | ||
| h2h | 2021-05-29 | FC Cincinnati |  | 0-1 |  | NE Revolution | Grp.East | ||
| h2h | 2021-05-23 | Houston Dynamo |  | 2-1 |  | Vancouver Whitecaps | Grp.West | ||
| h2h | 2021-05-15 | New York City FC |  | 1-1 | | Toronto FC | Grp.East | ||
| h2h | 2021-05-01 | Real Salt Lake |  | 3-1 | | Sporting KC | Grp.West | ||
| h2h | 2021-04-24 | New York City FC | | 5-0 | | FC Cincinnati | Grp.East | ||
