| 2021/07/29 | Sonacos Djourbel |  | 0-0 (3-5 pens) |  | Casa-Sports | ||||
| 2021/08/21 | Génération Foot |  | 0-3 |  | Diambars de Saly | ||||
| ASC Diaraf |  | 3-1 |  | RS Yoff | |||||
| NGB Niary Tally |  | 2-3 |  | Demba Diop | |||||
| 2021/08/22 | ETICS |  | 2-0 |  | US Gorée | ||||
| 2021/08/27 | CNEPS Excellence |  | 1-2 |  | AS Pikine | ||||
| 2021/08/28 | ASSUR |  | 0-1 |  | AS Douanes | ||||
| Stade Mbour |  | 4-2 |  | Guédiawaye |
